Statistics of Primera División Uruguaya in season 1922.
It was contested by 12 teams, and Nacional won the championship.
| Pos | Club | P | W | D | L | GF | GA | Pts |
| 1 | Nacional | 22 | 15 | 6 | 1 | 48 | 7 | 36 |
| 2 | Montevideo Wanderers | 22 | 15 | 5 | 2 | 32 | 9 | 35 |
| 3 | Rampla Juniors | 22 | 10 | 8 | 4 | 22 | 37 | 28 |
| 4 | Peñarol | 22 | 12 | 3 | 7 | 36 | 7 | 27 |
| 5 | Lito | 22 | 8 | 8 | 6 | 26 | 20 | 24 |
| 6 | Belgrano | 22 | 8 | 7 | 7 | 16 | 21 | 23 |
| 7 | Liverpool | 22 | 7 | 8 | 7 | 23 | 13 | 22 |
| 8 | Universal | 22 | 6 | 9 | 7 | 22 | 21 | 21 |
| 9 | Central | 22 | 4 | 8 | 10 | 22 | 15 | 16 |
| 10 | Uruguay Onward | 22 | 4 | 7 | 11 | 16 | 29 | 15 |
| 11 | Charley | 22 | 3 | 4 | 15 | 11 | 45 | 10 |
| 12 | Dublin | 22 | 1 | 3 | 18 | 5 | 55 | 5 |
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